Systems biology-driven approach to unravel and revert the mechanisms responsible for poor immune responses in the elderly

Funding: Federal Ministry for Education and Research (BMBF)
Duration: 1.2.2011 – 31.1.2014

As people get older so does the immune system. This phenomenon of ‘immunosenescence’ leads to an increased susceptibility to infection and a lower vaccination success, for example against influenza. The GerontoShield project under the coordination of Prof. Guzmàn (Helmholtz Centre for Infection Research) aims to generate mathematical models of immune pathways from various data sources. To this end our group contributes data from murine dendritic cells stimulated with various adjuvants, which are to be analyzed for their surface markers, cytokine production and gene expression profiles.