Synthetic Biology for the Design and Production of Antibiotic Peptides

Funding: European Union – Seventh Framework Program
Duration: September 2013 – August 2017

The Seventh Framework Program funded SYNPEPTIDE project (lead by Prof. Dr. Sven Panke, ETH Zürich) joins multiple European scientific groups to use synthetic biology for the design and production of novel peptide antibiotics.
In the preceding SYNMOD project, molecular modules have been selected and recombined to obtain enhanced and new functions and a technology for high throughput screening for antimicrobial activity has been established. The SYNPEPTIDE project will now optimize previously established techniques and include additional features like the site specific co-translational incorporation of non-canonical amino acids as well as additional posttranslational modification machineries to obtain a highly diversified number of synthetic and redesigned (l)antibiotic peptides.

Further information:


The lantibiotic nisin of Lactococcus lactis